Anti-Inflammatory Diet Home Page...
Subscribe to Anti-Inflammatory Diet RSS feeds...
Free Anti-inflammatory diet summary... Anti-inflammation diet weight loss story... 
Home Foods to Eat Foods to Avoid Exercise Supplements Weight Loss News Diabetes News Your Concerns Archived Reports

Bookmark Us: Yahoo Simpy Technorati Email a friend Print

Low-density lipoproteins are more electronegatively charged in type 1 than in type 2 diabetes mellitus.

<< Prev Report
Refine Your Search:

All Words Any Words
Next Report >>

Multifactorial etiology is involved in premature atherosclerosis related to diabetes. Most of the mechanisms that are responsible for the etiology in diabetes have remained unsolved so far. Type 1 diabetes is associated with a favorable lipid pattern and with microangiopathy, which is not true for type 2 diabetes, which is related to dyslipidemia and macroangiopathy. The aim of this work was to evaluate the degree of LDL modification related to the types of diabetes. The question is whether the LDL could be differently modified since the pathogenesis of type 1 and type 2 diabetes is different. Thirty-one type 1 (19 male and 12 female) and thirty type 2 (18 male and 12 female) diabetic patients were included in this study. Isolated LDL was analyzed by capillary electrophoresis for diene conjugate content and for electronegativity. LDL from type 1 diabetes subjects showed the highest electrophoretic mobility (P = 0.000). Instead, the diene conjugates contents were higher in the type 2 patients with HbA1c levels > 8% (P = 0.007). In conclusion, the increased diene content in type 2 diabetic subjects in poor glycemic control and the highest LDL mobility found in type 1 subjects show that the LDL undergoes different modifications. In type 2 patients, electronegative LDL are in a state of higher susceptibility to oxidation, whereas in type 1 subjects the finding of electronegative lipoproteins could provide an index of the relative atherogenicity of circulating LDL, especially as LDL has higher electrophoretic mobility than normal subjects. Publication Types: Comparative Study, Research Support, Non-U.S. Gov't

Keywords: electrophoretic mobility, diabetes, subjects, mobility, higher, diene, patients, related

Authored by Gambino R, Pisu E, Pagano G, Cassader M. Department of Internal Medicine, University of Turin, Italy.

Published in Lipids. 2006 Jun;41(6):529-33. The full report is available online. link   A subscription to the periodical may be required.

<< Prev Report Next Report >>

* All information on is for educational purposes only. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Before changing your diet, or adding supplements to your diet, or beginning an exercise program, everyone should consult a qualified and licensed health practitioner; a physician, dietician or similar professional.

spacer spacer
spacer foods to eat...

Over 1,532 new health studies are published every day ― 559,288 per year. Join our weekly update program to stay informed...

» About Health Updates



Donate $5 or $10
to help us promote
anti-inflammatory health.

Bigger Font Size Smaller Font Size Left Align Justify Align Right Align Bookmark This Page
Search 3.1 Million
Health Studies

» List of 4,000+ Diseases


Subscribe to
Health Reports

Add to Google Reader or Homepage
Subscribe in NewsGator Online
Subscribe in Bloglines
Add to Excite MIX
Add to netvibes
Add to fwicki
Add to My AOL
Add to The Free Dictionary

About Us Contact Us Privacy Free Newsletter Health FAQs Terms of Use

 Subscribe in a reader

© 2010, All Rights Reserved.     Contact:

Replace omega-6 vegetable oils with omega-9 olive oil... Eat oily fish like tuna, sardines, anchovy, salmon, herring... Beans, lentils, peas add fiber... Nine or more 3-ounce servings of fruits or vegetables per day...