Cytokine and anti-cytokine therapy for asthma.
Cytokines play a critical role in the pathogenesis of asthma. Asthma resolution may depend on the correction of dysregulated cytokine expression, which is a characteristic feature of this chronic inflammatory disease. It is, therefore, not surprising that attempts have been made to either block cytokines present at elevated levels or to substitute cytokines that are insufficiently expressed in asthma. In this article, the results of these studies are discussed, and the obtained insights regarding asthma pathogenesis and new treatment options are summarized.
Keywords: asthma, cytokines
Authored by Simon HU. Department of Pharmacology, University of Bern, Friedb�hlstrasse 49, CH-3010 Bern, Switzerland. firstname.lastname@example.org
Published in Curr Allergy Asthma Rep. 2006 Mar;6(2):117-21. The full report is available online. A subscription to the periodical may be required.
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