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Cytokines as potential therapeutic targets for inflammatory skin diseases.

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A network of pro-inflammatory cytokines is a central feature in the pathophysiology of cutaneous inflammatory diseases. Thus, the delineation of precise roles for particular cytokines and the development of cytokine-directed therapeutics have become areas of intense investigation. While anti-TNF therapeutics have proven to be effective for the treatment of psoriasis, clinical investigations have now begun with other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development too. In this short review, we summarize key findings from a recent workshop on cytokines as potential therapeutic targets for inflammatory skin diseases.

Keywords: that target, therapeutics have, cytokine directed, cytokines, therapeutics, cytokine, inflammatory

Authored by Numerof RP, Dinarello CA, Asadullah K. RBA Dermatology USA, Berlex Biosciences, 2600 Hilltop Drive, PO Box 4099, Richmond, CA 94804-0099, USA.

Published in Eur Cytokine Netw. 2005 Jun;16(2):101-3. The full report is available online. link   A subscription to the periodical may be required.

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