Anti-Inflammatory Diet Home Page...
 
Web Level1Diet.com
Subscribe to Anti-Inflammatory Diet RSS feeds...
Subscribe
Free Anti-inflammatory diet summary... Anti-inflammation diet weight loss story... 
Home Foods to Eat Foods to Avoid Exercise Supplements Weight Loss News Diabetes News Your Concerns Archived Reports

Bookmark Us: Yahoo Del.icio.us Simpy Technorati Email a friend Print



The IL-12 family of cytokines in infection, inflammation and autoimmune disorders.

<< Prev Report
Refine Your Search:

All Words Any Words
Next Report >>



Cytokines are critical coordinators of the immune response necessary for resolving bacterial and viral assaults on the immune system. In particular, the IL-12 family of cytokines are key players in the regulation of T cell responses. These responses are orchestrated by monocytes, macrophages, and dendritic cells which produce the members of the IL-12 family of cytokines in response to infection. IL-27 and IL-23 are two cytokines that are related to IL-12; these cytokines share homology at the subunit, receptor, and signalling levels. IL-12 is composed of p35 and p40 subunits, which, when combined together form the bioactive IL-12p70. IL-23 is composed of the IL-12p40 subunit as well as the IL-23p19 subunit, which shares homology with IL-12p35. IL-27 is composed of EBI3 and p28. These three cytokines activate similar members of the JAK/STAT signalling pathways as a result of homology in their receptor components. Production of these cytokines by activated monocytes, macrophages, and dendritic cells results in the activation and differentiation of T cells. In spite of their similarity, each of these cytokines has specific roles in the regulation of immune responses. IL-12 is required for the induction of IFN-gamma production, critical for the induction of Th1 cells. IL-27 has been shown to play a role in the induction of Th1 cells from naive T cells, whereas IL-23 has been demonstrated to play a key role in the induction of the newly described Th17 cells. Recently, a novel heterodimeric and anti-inflammatory cytokine composed of the IL-12p35 and EBI3 subunits has been identified as IL-35. The biological properties of the IL-12 family of cytokines, the signalling pathways mediated by these cytokines and their role in infection, inflammation, and autoimmune diseases will be the focus of this review.


Keywords: these cytokines, signalling pathways, dendritic cells, monocytes macrophages, cytokines, cells, composed, induction, signalling, subunit, homology, responses, immune, family

Authored by Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. Department of Microbiology and Immunology, Queen's University, Kingston ON, Canada.

Published in Inflamm Allergy Drug Targets. 2009 Mar;8(1):40-52. The full report is available online. link   A subscription to the periodical may be required.



<< Prev Report Next Report >>












* All information on Level1Diet.com is for educational purposes only. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Before changing your diet, or adding supplements to your diet, or beginning an exercise program, everyone should consult a qualified and licensed health practitioner; a physician, dietician or similar professional.




spacer spacer
spacer
Level1Diet.com foods to eat...
   


DO YOU KNOW ?
Over 1,532 new health studies are published every day ― 559,288 per year. Join our weekly update program to stay informed...
spacer

spacer
» About Health Updates


spacer

HAVE WE
HELPED YOU?

Donate $5 or $10
to help us promote
anti-inflammatory health.


spacer
Bigger Font Size Smaller Font Size Left Align Justify Align Right Align Bookmark This Page
spacer
Search 3.1 Million
Health Studies


» List of 4,000+ Diseases
spacer
   

spacer




Subscribe to
Level1Diet.com
Health Reports


Add to Google Reader or Homepage
Subscribe in NewsGator Online
Subscribe in Bloglines
Add to Excite MIX
Add to netvibes
Add to fwicki
Add to My AOL
Add to The Free Dictionary



About Us Contact Us Privacy Free Newsletter Health FAQs Terms of Use

 Subscribe in a reader

© 2010 Level1Diet.com, All Rights Reserved.     Contact:

Replace omega-6 vegetable oils with omega-9 olive oil... Eat oily fish like tuna, sardines, anchovy, salmon, herring... Beans, lentils, peas add fiber... Nine or more 3-ounce servings of fruits or vegetables per day...