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Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients.

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INTRODUCTION: The aim of the study was to describe the levels of circulating monocyte/macrophage pro-inflammatory cytokines (TNF-alpha, IL-1beta IL-6, and IL-8) and an anti-inflammatory cytokine (IL-10) in inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients and healthy controls. MATERIALS AND METHODS: The study was conducted on 15 healthy individuals, 20 patients with ulcerative colitis (UC), 12 with Crohn's disease (CD), and 15 with CRC (Dukes' stage B). Blood serum cytokine levels were measured by ELISA. RESULTS: The patients with UC had significantly higher levels of the pro-inflammatory cytokines and of circulating IL-10 than the healthy controls. The patients with CD and CRC had the same specific pattern of serum cytokines of significantly elevated levels of the pro-inflammatory cytokines, but the IL-10 levels were within the range found in the healthy individuals. CONCLUSIONS: Thus our results demonstrate that both IBD and CRC are linked with an intensified production of a wide array of monocyte/macrophage pro-inflammatory cytokines which is not accompanied by elevated levels of circulating IL-10, except for its insufficiently inhibitory elevation in UC patients.


Keywords: inflammatory cytokines, patients with, levels were, elevated levels, healthy individuals, healthy controls, monocyte macrophage, levels, inflammatory, patients, cytokines, healthy, circulating

Authored by Szkaradkiewicz A, Marciniak R, Chudzicka-Struga?a I, Wasilewska A, Drews M, Majewski P, Karpi?ski T, Zwo?dziak B. Department of Medical Microbiology, University of Medical Sciences, Wieniawskiego 3, 61-712 Pozna?, Poland. szkaradkiewicza@poczta.onet.pl

Published in Arch Immunol Ther Exp (Warsz). 2009 Jul-Aug;57(4):291-4. Epub 2009 Jul 4. The full report is available online. link   A subscription to the periodical may be required.



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