Cytokines in Sj�gren's syndrome.
Cytokines play a central role in the regulation of immunity and are often found to be deregulated in autoimmune diseases. Sj�gren's syndrome is a chronic autoimmune disease characterized by inflammation and loss of secretory function of the salivary and lachrymal glands. This review highlights the current knowledge of the expression and the function of pro- and anti-inflammatory cytokines both locally and systemically in Sj�gren's syndrome patients. In the salivary glands, saliva and serum of these patients, many pro-inflammatory cytokines are upregulated. Concomitantly, most anti-inflammatory cytokines are not detectable or are expressed at low levels. Besides a role in inflammation, cytokines are also thought to be involved in salivary gland dysfunction by directly interfering with the epithelial cells in the glands. Future research on the role of novel cytokines in Sj�gren's syndrome in combination with a better understanding of the effect of cytokines on exocrine dysfunction will aide the identification of the best therapeutic targets for Sj�gren's syndrome.
Keywords: anti inflammatory cytokines, inflammatory cytokines, anti inflammatory, cytokines, syndrome, sjgren, inflammatory, salivary, glands
Authored by Roescher N, Tak PP, Illei GG. Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. firstname.lastname@example.org
Published in Oral Dis. 2009 Nov;15(8):519-26. Epub 2009 Jun 10. The full report is available online. A subscription to the periodical may be required.
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