Changes in cerebrospinal fluid cytokine expression in tuberculous meningitis patients with treatment.
BACKGROUND: The prevalence of tuberculous meningitis (TBM) is very high in developing areas of the world. Inflammation and cytokine patterns produced by T lymphocytes play an important role in susceptibility to infections. The inflammatory response and production of cytokines in the cerebrospinal fluid (CSF) of patients with TBM are well documented. Conversely, little is known about the role of pro- and anti-inflammatory cytokines in the CSF of TBM patients. The goal of the present study was to estimate the level of proinflammatory cytokine and anti-inflammatory cytokine levels in CSF samples from TBM patients. MATERIALS AND METHODS: To study this, in vivo levels of IL-2 and IFN-gamma (proinflammatory cytokines), and IL-10 (anti-inflammatory cytokine) in the CSF of 60 adult TBM patients and 50 age- and sex-matched non-TBM controls were measured. These cytokines were estimated in the CSF of TBM patients before and after starting treatment. RESULTS: High levels of proinflammatory cytokines as compared to anti-inflammatory cytokines were found in TBM patients before treatment. However, CSF samples from TBM patients after treatment showed elevated levels of anti-inflammatory and low levels of proinflammatory cytokines. CONCLUSIONS: We hypothesize that an increase in anti-inflammatory cytokines during treatment may indicate a favorable response.
Keywords: anti inflammatory cytokines, anti inflammatory cytokine, anti inflammatory, proinflammatory cytokines, inflammatory cytokines, patients before, cytokines were, samples from, inflammatory cytokine, cytokines, patients, inflammatory, levels, treatment, proinflammatory, cytokine
Authored by Kashyap RS, Deshpande PS, Ramteke SR, Panchbhai MS, Purohit HJ, Taori GM, Daginawala HF. Biochemistry Research Laboratory, Central India Institute of Medical Sciences, Nagpur, India.
Published in Neuroimmunomodulation. 2010;17(5):333-9. Epub 2010 Apr 17. The full report is available online. A subscription to the periodical may be required.
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